Scholarly Commons @ MU
Hartley, Scott
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Recent Submissions
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Data archive for "Mechanisms of Chiral Induction in Foldamers"
Foldamers, oligomers that adopt well-defined conformations, represent an efficient strategy toward nanoscale structural complexity. While most foldamers fold into (chiral) helices, many abiotic foldamers are built from ... -
Data archive for "Controlling Carbodiimide-Driven Reaction Networks Through the Reversible Formation of Pyridine Adducts"
Carbodiimide-driven anhydride formation from carboxylic acids is useful in a variety of non-equilibrium systems. While multiple strategies to control deactivation rates (anhydride hydrolysis) have been reported, control ... -
Data archive for "Transient Polymers through Carbodiimide-driven Assembly"
Biochemical systems make use of out-of-equilibrium polymers generated under kinetic control. Inspired by these systems, abiotic supramolecular polymers driven by chemical fuel reactions have recently been reported. Conversely, ... -
Data archive for "Carbodiimide-driven toughening of interpenetrated polymer networks"
Recent work has demonstrated that temporary crosslinks in polymer networks generated by chemical “fuels” afford materials with large, transient changes in their mechanical properties. This can be accomplished in ... -
Data archive for "Carbodiimide-induced formation of transient polyether cages"
The use of “fuel” compounds to drive chemical systems out of equilibrium is currently of interest because of the potential for temporally controlled, responsive behavior. We have recently shown that transiently formed crown ... -
Data archive for "Engineering chiral induction in centrally functionalized ortho-phenylenes"
Work on foldamers, non-biological oligomers that mimic the hierarchical structure of biomacromolecules, continues to yield new architectures of ever increasing complexity. o-Phenylenes, a class of helical aromatic foldamers, ... -
Data archive for "Conformational control of ortho-phenylenes by terminal amides"
Control over the folding of oligomers, be it broad induction of a preferred helical handedness or subtle changes in the orientations of individual functional groups, is important for applications ranging from molecular ... -
Data archive for "Guest-driven control of folding in a crown-ether-functionalized ortho-phenylene"
A crown-ether-functionalized o-phenylene tetramer has been synthesized and coassembled with monotopic and ditopic, achiral and chiral secondary ammonium ion guests. NMR spectroscopy shows that the o-phenylene forms both ... -
Data archive for "Fluorine Labeling of ortho-Phenylenes to Facilitate Conformational Analysis"
1H NMR spectroscopy is a powerful tool for the conformational analysis of ortho-phenylene foldamers in solution. However, as o-phenylenes are integrated into ever more complex systems, we are reaching the limits of what ... -
Data archive for "Substituent effects on transient, carbodiimide-induced geometry changes in diphenic acids"
Nucleotide-induced conformational changes in motor proteins are key to many important cell functions. Inspired by this biological behavior, we report a simple chemically fueled system that exhibits carbodiimide-induced ... -
Data archive for "Folding-controlled assembly of ortho-phenylene-based macrocycles"
The self-assembly of foldamers into macrocycles is a simple approach to non-biological higher-order structure. Previous work on the co-assembly of ortho-phenylene foldamers with rod-shaped linkers has shown that folding ... -
Data archive for "Chemically fueled transient geometry changes in diphenic acids"
Transient changes in molecular geometry are key to the function of many important biochemical systems. Here, we show that diphenic acids undergo out-of-equilibrium changes in dihedral angle when reacted with a carbodiimide ... -
Data archive for "ortho‐Phenylene‐based macrocyclic hydrocarbons assembled using olefin metathesis"
While many foldamer systems reliably fold into well‐defined secondary structures, higher order structure remains a challenge. A simple strategy for the organization of folded subunits in space is to link them together ... -
Data archive for "Dissipative assembly of macrocycles comprising multiple transient bonds"
Dissipative (nonequilibrium) assembly powered by chemical fuels has great potential for the creation of new adaptive chemical systems. However, while molecular assembly at equilibrium is routinely used to prepare complex ... -
Data archive for "Structure–property effects in the generation of transient aqueous benzoic acid anhydrides by carbodiimide fuels"
The design of dissipative systems, which operate out-of-equilibrium by consuming chemical fuels, is challenging. As yet, there are a few examples of privileged fuel chemistries that can be broadly applied in abiotic systems ... -
Data archive for "Macrocycles of higher ortho-phenylenes: assembly and folding"
Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in ... -
Data archive for "Chemically fueled covalent crosslinking of polymer materials"
Transiently crosslinked dynamic polymer networks are developed, using carbodiimide hydration to link carboxylic acids as anhydrides. From aqueous polymer solutions, non-equilibrium hydrogels are transiently formed, which ...
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