Faculty and Graduate Student data setshttp://hdl.handle.net/2374.MIA/61092024-03-29T11:32:24Z2024-03-29T11:32:24ZDifferential Effects of Lateral and Medial Entorhinal Cortex Lesions on Trace, Delay and Contextual Fear MemoriesEast, Brett S. JrBrady, Laura R.Quinn, Jennifer J.http://hdl.handle.net/2374.MIA/67762022-01-06T16:43:03ZDifferential Effects of Lateral and Medial Entorhinal Cortex Lesions on Trace, Delay and Contextual Fear Memories
East, Brett S. Jr; Brady, Laura R.; Quinn, Jennifer J.
Data set only
Validation and Deployment of a Direct Saliva Real-Time RT-PCR Test on Pooled Samples for COVID-19 Surveillance TestingWilson, Timothyhttp://hdl.handle.net/2374.MIA/67672021-10-11T20:02:35ZValidation and Deployment of a Direct Saliva Real-Time RT-PCR Test on Pooled Samples for COVID-19 Surveillance Testing
Wilson, Timothy
Minimal Data Set with anonymized indicators used for validation and analysis of saliva PCR test results, Ct values, diagnostic confirmations, and summary statistics.
Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory ReconsolidationCampbell, Tiffany LKochli, Daniel E.McDaniel, Mitch A.Myers, Mallory K.Dunn, Mallory E.Diana, Victoria A.Quinn, Jennifer J.http://hdl.handle.net/2374.MIA/67422021-07-30T20:33:06ZUsing Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation
Campbell, Tiffany L; Kochli, Daniel E.; McDaniel, Mitch A.; Myers, Mallory K.; Dunn, Mallory E.; Diana, Victoria A.; Quinn, Jennifer J.
Reconsolidation is a process by which memories are destabilized, updated, and then restabilized. Strong memories are resistant to undergoing reconsolidation. Here, we addressed whether an overtrained fear memory could be made susceptible to reconsolidation by first extinguishing, and then renewing, the memory. Rats were trained with ten tone-footshock pairings, followed by eight days of tone extinction in the training context. The next day, rats were placed into a second con-text and memory for the tone was renewed/reactivated with a single tone presentation. Immedi-ately following reactivation, rats received an injection of midazolam or vehicle. Rats were then tested for freezing to the tone in a third context. Midazolam had no effect in rats that did not un-dergo tone extinction, but significantly attenuated freezing to the tone in extinguished rats. Thus, rats that received tone extinction underwent tone memory reconsolidation following its renewal. In a second experiment, we administered the reactivation session and midazolam injections prior to extinction. Midazolam had no effect and rats extinguished at a rate similar to controls. These data suggest that strong emotional memories are capable of updating following weakening of memory expression through extinction.
Nitric Oxide Metabolites in Hypoxia Freezing and Hibernation in wood frogsWilliams, Bethanyhttp://hdl.handle.net/2374.MIA/62362018-04-26T15:14:39ZNitric Oxide Metabolites in Hypoxia Freezing and Hibernation in wood frogs
Williams, Bethany
Nitric oxide (NO) is a gaseous free radical that in diverse organisms performs many signaling and protective functions, such as vasoregulation, inhibition of apoptosis, antioxidation, and metabolic suppression. Increased availability of NO may be especially important during life history periods when organisms must contend with multiple stresses. We investigated dynamics of the NO metabolites, nitrite (NO2-) and nitrate (NO3-), in the blood plasma, heart, liver, and skeletal muscle of the wood frog (Rana sylvatica), an amphibian that endures chronic cold, freezing, hypoxia, dehydration, and extended aphagia during hibernation. We found elevated concentrations of NO2- and/or NO3- in the plasma (up to 4.1-fold), heart (3.1-fold), and liver (up to 4.1-fold) of frogs subjected to experimental hypoxia (24 h, 4°C), and in the liver (up to 3.8-fold) of frogs exposed to freezing (48 h, -2.5 °C), suggesting that increased NO availability aids in survival of these stresses. During a 38-week period of simulated hibernation, NO2- and/or NO3- increased in the plasma (up to 10.4-fold), heart (up to 3.3-fold), and liver (5.0-fold) during an initial 5-week winter-conditioning regimen and generally remained elevated thereafter. In hibernation, plasma NO2- was higher in frogs indigenous to Interior Alaska than in conspecifics from a more temperate locale (southern Ohio), suggesting that NO availability is matched to the severity of environmental conditions prevailing in winter. Our results, together with published values for other species, suggest that the NO protection system is of general importance in the stress adaptation of vertebrates.