Data archive for "Engineering chiral induction in centrally functionalized ortho-phenylenes"

Abstract

Work on foldamers, non-biological oligomers that mimic the hierarchical structure of biomacromolecules, continues to yield new architectures of ever increasing complexity. o-Phenylenes, a class of helical aromatic foldamers, are well-suited to this area because of their structural simplicity and the straightforward characterization of their folding in solution. However, combining multiple foldamer subunits into single species requires, by definition, control over folding handedness to obtain well-defined species. Control over o-phenylene twist sense is currently lacking. While chiral induction from groups at their termini has been demonstrated, it would be useful to instead direct twisting from internal positions in order to leave their ends free. Here, we explore chiral induction in a series of o-phenylenes with chiral imides at their centers. Conformational behavior has been studied by NMR and CD spectroscopies and DFT calculations. Chiral induction in otherwise unfunctionalized o-phenylenes is generally poor. However, strategic functionalization of the helix surface with trifluoromethyl and methyl groups allows it to better interact with the imide groups, greatly increasing diastereomeric excesses. The sense of chiral induction is consistent with computational models that suggest that it primarily arises from a steric effect.