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dc.contributor.authorJayalath, Isuru M.
dc.contributor.authorWang, Hehe
dc.contributor.authorMantel, Georgia
dc.contributor.authorKariyawasam, Lasith S.
dc.contributor.authorHartley, C. Scott
dc.description.abstractTransient changes in molecular geometry are key to the function of many important biochemical systems. Here, we show that diphenic acids undergo out-of-equilibrium changes in dihedral angle when reacted with a carbodiimide chemical fuel. Treatment of appropriately functionalized diphenic acids with EDC (N-(3-(dimethylamino)propyl)-N′-ethylcarbodiimide hydrochloride) yields the corresponding diphenic anhydrides, reducing the torsional angle about the biaryl bond by ∼45°, regardless of substitution. In the absence of steric resistance, the reaction is well-described by a simple mechanism; the resulting kinetic parameters can be used to derive important properties of the system, such as yields and lifetimes. The reaction tolerates steric hindrance ortho to the biaryl bond, although the competing formation of (transient) byproducts complicates quantitative analysis.en_US
dc.rightsAttribution 3.0 United States*
dc.titleData archive for "Chemically fueled transient geometry changes in diphenic acids"en_US
dc.typeJournal Articleen_US

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  • Hartley, Scott
    Dr. Scott Hartley - Professor, Chemistry & Biochemistry

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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States